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Article

von Willebrand factor storage requires intact prosequence cleavage site.

European journal of cell biology - 1 Feb 1993

Journet A M, Saffaripour S, Cramer E M, Tenza D, Wagner D D

Abstract excerpt

Large multimers of the adhesive glycoprotein von Willebrand factor (vWf) are stored in endothelial cells in rod-shaped granules called Weibel-Palade bodies, while small multimers are secreted constitutively. Expression of pro-vWf in other cells with a regulated pathway of secretion, results in formation of vWf-containing storage granules that have a morphology similar to Weibel-Palade bodies. vWf expressed...

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PMID: 8462598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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von Willebrand factor storage requires intact prosequence cleavage site.PMID 8462598Read ↗

Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage.Semantic proximity Read ↗

Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.Semantic proximity Read ↗

Dispatch and delivery at the ER–Golgi interface: how endothelial cells tune their hemostatic responseSemantic proximity Read ↗

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cellsSemantic proximity Read ↗

von Willebrand factor propeptide missense variants affect anterograde transport to Golgi resulting in ER retention.Semantic proximity Read ↗

Loss of cysteine 584 impairs the storage and release, but not the synthesis of von Willebrand factor.Semantic proximity Read ↗

The dominant p.Thr274Pro mutation in the von Willebrand factor propeptide causes the von Willebrand disease type 1 phenotype in two unrelated patients.Semantic proximity Read ↗

von Willebrand factor remodeling during exocytosis from vascular endothelial cells.Semantic proximity Read ↗

How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies.Semantic proximity Read ↗

Functional architecture of Weibel-Palade bodiesSemantic proximity Read ↗

Storage and secretion of naturally occurring von Willebrand factor A domain variants.Semantic proximity Read ↗

Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage.Semantic proximity Read ↗

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