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Article

Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation.

Haematologica - 1 Jun 2012

Wang Jiong-Wei, Groeneveld Dafna J, Cosemans Guy, Dirven Richard J, Valentijn Karine M, Voorberg Jan, Reitsma Pieter H, Eikenboom Jeroen

Abstract excerpt

BACKGROUND: Mutations of cysteine residues in von Willebrand factor are known to reduce the storage and secretion of this factor, thus leading to reduced antigen levels. However, one cysteine mutation, p.Cys2773Ser, has been found in patients with type 2A(IID) von Willebrand's disease who have no...

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PMID: 22207689
DOI: 10.3324/haematol.2011.057216
PMCID: PMC3366651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22207689-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation.PMID 22207689Read ↗

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