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Article

Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage.

Thrombosis and haemostasis - 20 Dec 1993

Journet A M, Saffaripour S, Wagner D D

Abstract excerpt

Biosynthesis of the adhesive glycoprotein von Willebrand factor (vWf) by endothelial cells results in constitutive secretion of small multimers and storage of the largest multimers in rod-shaped granules called Weibel-Palade bodies. This pattern is reproduced by expression of pro-vWf in heterologous cells with a regulated pathway of secretion, that store the recombinant protein in similar elongated granules. In...

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PMID: 8165600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage.PMID 8165600Read ↗

von Willebrand factor storage requires intact prosequence cleavage site.Semantic proximity Read ↗

Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage.Semantic proximity Read ↗

Von Willebrand disease and Weibel-Palade bodies.Semantic proximity Read ↗

Weibel-Palade bodies: a window to von Willebrand disease.Semantic proximity Read ↗

Domains involved in multimer assembly of von willebrand factor (vWF): multimerization is independent of dimerization.Semantic proximity Read ↗

von Willebrand factor-T441N, a novel missense variant in the von Willebrand factor D2 domain, exhibits impaired multimerization and deformed Weibel-Palade bodies.Semantic proximity Read ↗

The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF.Semantic proximity Read ↗

Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.Semantic proximity Read ↗

How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies.Semantic proximity Read ↗

Functional architecture of Weibel-Palade bodiesSemantic proximity Read ↗

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cellsSemantic proximity Read ↗

The dominant p.Thr274Pro mutation in the von Willebrand factor propeptide causes the von Willebrand disease type 1 phenotype in two unrelated patients.Semantic proximity Read ↗

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