Article
Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage.
Thrombosis and haemostasis - 20 Dec 1993
Journet A M, Saffaripour S, Wagner D D
Abstract excerpt
Biosynthesis of the adhesive glycoprotein von Willebrand factor (vWf) by endothelial cells results in constitutive secretion of small multimers and storage of the largest multimers in rod-shaped granules called Weibel-Palade bodies. This pattern is reproduced by expression of pro-vWf in heterolog...
Topics
- Animals
- Base Sequence
- Cell Line
- Chromosome Deletion
- Humans
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Protein Precursors
- Protein Structure, Tertiary
- Specimen Handling
- Tumor Cells, Cultured
- von Willebrand Factor