Article

Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon System

1994-02-01

Abstract excerpt

Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as regulators of the type I interferon (IFN) system; the former functions as a transcriptional activator, and the latter represses IRF-1 function by competing for the same cis elements. More recent studies have revealed new roles of the two factors in the regulation of cell growth; IRF-1 a...

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Literature Corpus work: 9d3f0e6e-9b77-5303-8e06-1c0b18795683
DOI: 10.1128/mcb.14.2.1500-1509.1994

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