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The Yin and Yang of Type I IFNs in Cancer Promotion and Immune Activation

1 Sept 2021

Abstract excerpt

Type I Interferons (IFNs) are key regulators of natural and therapy-induced host defense against viral infection and cancer. Several years of remarkable progress in the field of oncoimmunology have revealed the dual nature of these cytokines. Hence, Type I IFNs may trigger anti-tumoral responses, while leading immune dysfunction and disease progression. This dichotomy relies on the duration and intensity of the...

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PMID: 34571733
DOI: 10.3390/biology10090856

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