Article
Severely decreased MARCKS expression correlates with ras reversion but not with mitogenic responsiveness.
Oncogene - 1 Mar 1993
Wojtaszek P A, Stumpo D J, Blackshear P J, Macara I G
Abstract excerpt
Phorbol ester-inducible phosphorylation of MARCKS, the '80-kDa' substrate of protein kinase C, was undetectable in several phenotypically dominant, non-transformed revertants independently derived from the ras-transformed cell line NIH3T3 DT-ras. Extremely low expression of MARCKS protein account...
Topics
- 3T3 Cells
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA
- Genes, ras
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice
- Myristoylated Alanine-Rich C Kinase Substrate
- Phenotype
- Phosphorylation
- Protein Kinase C
- Proteins
- Tetradecanoylphorbol Acetate
- Transfection