Article
Severely decreased MARCKS expression correlates with ras reversion but not with mitogenic responsiveness.
Oncogene - 1 Mar 1993
Wojtaszek P A, Stumpo D J, Blackshear P J, Macara I G
Abstract excerpt
Phorbol ester-inducible phosphorylation of MARCKS, the '80-kDa' substrate of protein kinase C, was undetectable in several phenotypically dominant, non-transformed revertants independently derived from the ras-transformed cell line NIH3T3 DT-ras. Extremely low expression of MARCKS protein accounted for this apparent lack of phosphorylation. MARCKS-encoding mRNA levels were correspondingly decreased relative to...
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