Article
Transgenic complementation of MARCKS deficiency with a nonmyristoylatable, pseudo-phosphorylated form of MARCKS: evidence for simultaneous positive and dominant-negative effects on central nervous system development.
Developmental biology - 15 Aug 1998
Kim H S, Swierczynski S L, Tuttle J S, Lai W S, Blackshear P J
Abstract excerpt
MARCKS is a widely expressed protein kinase C substrate that is essential for normal prenatal development of the central nervous system in mice. MARCKS-deficient mice exhibit universal perinatal mortality and numerous developmental abnormalities of the brain and retina. To determine which domains...
Topics
- Animals
- Central Nervous System
- Embryonic and Fetal Development
- Epitopes
- Gene Expression Regulation, Developmental
- Humans
- Immunohistochemistry
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice