Article
Structure and immune recognition of HLA-B27 antigens: implications for disease association.
Scandinavian journal of rheumatology. Supplement - 1 Jan 1990
López de Castro J A, Bragado R, Lauzurica P, López D, Rojo S
Abstract excerpt
HLA-B27 is strongly associated with susceptibility to ankylosing spondylitis and other spondyloarthropathies. Structural analysis of this antigen has revealed the existence of multiple variants, or subtypes, in human populations. The structural microheterogeneity of these subtypes deeply affects allospecific T cell recognition and most of it occurs at an spatial cluster within the peptide binding groove of the...
Topics
- Amino Acid Sequence
- Base Sequence
- Epitopes
- HLA-B27 Antigen
- Humans
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Polymorphism, Genetic
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta