Article
HLA-B15 peptide ligands are preferentially anchored at their C termini.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1999
Prilliman K R, Jackson K W, Lindsey M, Wang J, Crawford D, Hildebrand W H
Abstract excerpt
Therapies to elicit protective CTL require the selection of pathogen- and tumor-derived peptide ligands for presentation by MHC class I molecules. Edman sequencing of class I peptide pools generates "motifs" that indicate that nonameric ligands bearing conserved position 2 (P2) and P9 anchors provide the optimal search parameters for selecting immunogenic epitopes. To determine how well a motif represents its...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
