HLA-B15 peptide ligands are preferentially anchored at their C termini.

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Article

HLA-B15 peptide ligands are preferentially anchored at their C termini.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1999

Prilliman K R, Jackson K W, Lindsey M, Wang J, Crawford D, Hildebrand W H

Abstract excerpt

Therapies to elicit protective CTL require the selection of pathogen- and tumor-derived peptide ligands for presentation by MHC class I molecules. Edman sequencing of class I peptide pools generates "motifs" that indicate that nonameric ligands bearing conserved position 2 (P2) and P9 anchors provide the optimal search parameters for selecting immunogenic epitopes. To determine how well a motif represents its...

Topics

Alleles
Amino Acid Sequence
Antigen Presentation
Chromatography, High Pressure Liquid
Conserved Sequence
Cytosol
HLA-B Antigens
HLA-B15 Antigen
Humans
Ligands
Mass Spectrometry
Models, Molecular
Molecular Sequence Data
Peptide Fragments
Peptide Mapping

Source

Open in PubMed

Identifiers

PMID: 10358176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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