Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation.

doi:10.1128/JVI.64.9.4115-4122.1990

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Article

Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation.

Journal of virology - 1 Sept 1990

Ames R S, Holskin B, Mitcho M, Shalloway D, Chen M J

Abstract excerpt

We have previously shown that expression of the adenovirus E1A 12S or 13S products in NIH 3T3 fibroblasts induces susceptibility to the cytotoxic actions of tumor necrosis factor alpha (TNF alpha). A large number of studies have mapped the multiple biological functions of the 12S and 13S products to three highly conserved regions (CR) within the E1A sequence. Here we used plasmids coding for E1A deletion and...

Topics

Adenoviridae
Adenovirus Early Proteins
Animals
Cell Line
Cell Survival
Cell Transformation, Viral
Chromosome Deletion
Genes, tat
Globins
HIV
Human T-lymphotropic virus 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Oncogene Proteins, Viral

Recombinant Proteins

Trans-Activators

Transcriptional Activation

Transfection

Source

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Identifiers

PMID: 2143540
DOI: 10.1128/JVI.64.9.4115-4122.1990
PMCID: PMC247874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2143540-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation.PMID 2143540Read ↗

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