Article
Inhibition of IFN-stimulated gene expression and IFN induction of cytolytic resistance to natural killer cell lysis correlate with E1A-p300 binding.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1996
Routes J M, Li H, Bayley S T, Ryan S, Klemm D J
Abstract excerpt
Treatment of target cells with IFN induces resistance to NK cell lysis. This process is blocked by expression of E1A gene products in adenovirus (Ad)-infected and Ad-transformed cells. We compared the ability of adenovirus serotype 5 (Ad5) E1A exon 1 mutants to inhibit the induction of cytolytic...
Topics
- Cytotoxicity, Immunologic
- Exons
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Humans
- Immunity, Innate
- Interferons
- Killer Cells, Natural
- Mutation
- Nuclear Proteins
- Protein Binding
- Trans-Activators
- Transcription Factors
- Tumor Cells, Cultured