Article
Amino acid substitutions in the first complementarity-determining region of a murine T-cell receptor alpha chain affect antigen-major histocompatibility complex recognition.
The Journal of biological chemistry - 25 May 1990
Nalefski E A, Wong J G, Rao A
Abstract excerpt
The T-cell antigen receptor mediates recognition of foreign antigens physically associated with major histocompatibility complex (MHC) proteins. The tertiary structure of the T-cell receptor is thought to resemble that of immunoglobulin Fab fragments and to possess corresponding complementarity-d...
Topics
- Amino Acid Sequence
- Antigen-Antibody Complex
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- Blotting, Southern
- CD3 Complex
- Cell Line
- Flow Cytometry
- Histocompatibility Antigens
- Histocompatibility Antigens Class II
- Humans
- Kinetics
- Major Histocompatibility Complex
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Conformation