Amino acid substitutions in the first complementarity-determining region of a murine T-cell receptor alpha chain affect antigen-major histocompatibility complex recognition.

Abstract excerpt

The T-cell antigen receptor mediates recognition of foreign antigens physically associated with major histocompatibility complex (MHC) proteins. The tertiary structure of the T-cell receptor is thought to resemble that of immunoglobulin Fab fragments and to possess corresponding complementarity-determining regions (CDRs) that contact antigen-MHC. To test such a model for the T-cell receptor, we have generated...

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