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Article

Antibody domain mutants demonstrate autonomy of the antigen binding site.

The EMBO journal - 1 Apr 1990

Simon T, Rajewsky K

Abstract excerpt

We have constructed derivatives of a lambda I light chain-bearing anti-(4-hydroxy,3-nitrophenyl)acetyl (NP) antibody which have the V regions exchanged between heavy chains and light chains of the kappa or lambda I type. These antibodies are assembled and secreted normally, and bind haptenic and macromolecular ligands like the wild-type; similar results are obtained for monovalent heterodimers of VHCL and lambda...

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Identifiers

PMID: 2108860
DOI: 10.1002/j.1460-2075.1990.tb08209.x
PMCID: PMC551777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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