Article
The structural repertoire of the human V kappa domain.
The EMBO journal - 15 Sept 1995
Tomlinson I M, Cox J P, Gherardi E, Lesk A M, Chothia C
Abstract excerpt
In humans, the gene for the V kappa domain is produced by the recombination of one of 40 functional V kappa segments and one of five functional J kappa segments. We have analysed the sequences of these germline segments and of 736 rearranged V kappa genes to determine the repertoire of main chain conformations, or canonical structures, they encode. Over 96% of the sequences correspond to one of four canonical...
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