Article
The structural repertoire of the human V kappa domain.
The EMBO journal - 15 Sept 1995
Tomlinson I M, Cox J P, Gherardi E, Lesk A M, Chothia C
Abstract excerpt
In humans, the gene for the V kappa domain is produced by the recombination of one of 40 functional V kappa segments and one of five functional J kappa segments. We have analysed the sequences of these germline segments and of 736 rearranged V kappa genes to determine the repertoire of main chain...
Topics
- Amino Acid Sequence
- Binding Sites, Antibody
- Gene Rearrangement
- Genes, Immunoglobulin
- Germ Cells
- Humans
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Sequence Homology, Amino Acid
- Structure-Activity Relationship