Article
Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.
The American journal of pathology - 1 Sept 1995
Cordon-Cardo C
Abstract excerpt
Neoplastic diseases are characterized by uncoordinated cell growth. Cellular proliferation follows an orderly progression through the cell cycle, which is governed by protein complexes composed of cyclins and cyclin-dependent kinases. These complexes exert their regulatory function by phosphorylation of key proteins involved in cell cycle transitions, such as the product encoded by the retinoblastoma gene (pRB)....
Topics
- Animals
- Cell Cycle
- Cyclin-Dependent Kinases
- Cyclins
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Mutation
- Neoplasms
- Oncogenes
- Retinoblastoma Protein