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Article

Principles of tumor suppression.

Cell - 23 Jan 2004

Sherr Charles J

Abstract excerpt

Molecular genetic studies of familial cancer syndromes identified and defined the recessive nature of tumor suppressor genes and resolved the paradox of why tumors arising in such families exhibited an autosomally dominant pattern of inheritance. Subsequent characterization of tumor suppressor proteins revealed their widespread involvement in sporadic cancers and pinpointed key mechanisms that protect animals...

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Identifiers

PMID: 14744434
DOI: 10.1016/s0092-8674(03)01075-4

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