Article
Antioncogenes and human cancer.
Annual review of medicine - 1 Jan 1993
Carbone D P, Minna J D
Abstract excerpt
Multiple genetic lesions are thought to transform a normal cell into a malignant one, and both dominant and recessive genetic effects have been identified in this process. Antioncogenes (or tumor suppressor genes) act in a recessive manner, in which both maternal and paternal alleles need to be inactivated to abrogate normal function. The identification of these lesions is giving us insight into the regulatory...
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