Article
The GTPase-activating protein Rap1GAP uses a catalytic asparagine.
Nature - 13 May 2004
Daumke Oliver, Weyand Michael, Chakrabarti Partha P, Vetter Ingrid R, Wittinghofer Alfred
Abstract excerpt
Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by guanine-nucleotide-exchange factors (GEFs) and GTPase-activating proteins (GAPs). These GAPs increase the slow intrinsic GTPase reaction of...
Topics
- Adenosine Diphosphate
- Aluminum Compounds
- Asparagine
- Binding Sites
- Catalysis
- Catalytic Domain
- Crystallography, X-Ray
- Fluorides
- GTPase-Activating Proteins
- Guanosine Triphosphate
- Humans