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Article

The GTPase-activating protein Rap1GAP uses a catalytic asparagine.

Nature - 13 May 2004

Daumke Oliver, Weyand Michael, Chakrabarti Partha P, Vetter Ingrid R, Wittinghofer Alfred

Abstract excerpt

Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by guanine-nucleotide-exchange factors (GEFs) and GTPase-activating proteins (GAPs). These GAPs increase the slow intrinsic GTPase reaction of...

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PMID: 15141215
DOI: 10.1038/nature02505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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