Article
Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells.
The Journal of biological chemistry - 9 Mar 2001
Hiatt K K, Ingram D A, Zhang Y, Bollag G, Clapp D W
Abstract excerpt
Members of the Ras superfamily of signaling proteins modulate fundamental cellular processes by cycling between an active GTP-bound conformation and an inactive GDP-bound form. Neurofibromin, the protein product of the NF1 tumor suppressor gene, and p120GAP are GTPase-activating proteins (GAPs) for p21(Ras) (Ras) and negatively regulate output by accelerating GTP hydrolysis on Ras. Neurofibromin and p120GAP...
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