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The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation

16 Jun 2016

Abstract excerpt

Neurofibromatosis type 1 (NF1) and Legius syndrome are related diseases with partially overlapping symptoms caused by alterations of the tumor suppressor genes NF1 (encoding the protein neurofibromin) and SPRED1 (encoding sprouty-related, EVH1 domain-containing protein 1, Spred1), respectively. Both proteins are negative regulators of Ras/MAPK signaling with neurofibromin functioning as a Ras-specific GTPase...

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PMID: 27313208
DOI: 10.1073/pnas.1607298113

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The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivationPMID 27313208Read ↗

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