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Article

Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.

The Journal of biological chemistry - 1 Dec 1995

Mori S, Satoh T, Koide H, Nakafuku M, Villafranca E, Kaziro Y

Abstract excerpt

The neurofibromatosis type 1 (NF1) gene encodes a protein, neurofibromin, containing GTPase-activating protein-related domain (GRD) that stimulates intrinsic GTPase activity of Ras protein. By screening a randomly mutagenized NF1-GRD library in Saccharomyces cerevisiae, we isolated two NF1-GRD mutants (NF201 and NF204) with single amino acid substitutions, which suppress the heat shock-sensitive phenotype of the...

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PMID: 7499408
DOI: 10.1074/jbc.270.48.28834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.PMID 7499408Read ↗

Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.Semantic proximity Read ↗

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Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells.Semantic proximity Read ↗

Somatic mutations in the neurofibromatosis 1 gene in human tumors.Semantic proximity Read ↗

Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.Semantic proximity Read ↗

Characterization of Ras effector mutant interactions with the NF1-GAP related domain.Semantic proximity Read ↗

Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype.Semantic proximity Read ↗

The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.Semantic proximity Read ↗

Use of yeast two-hybrid system to evaluate Ras interactions with neurofibromin-GTPase-activating protein.Semantic proximity Read ↗

The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.Semantic proximity Read ↗

Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1Semantic proximity Read ↗

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