Article
p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Oncogene - 1 Feb 1993
Kalthoff H, Schmiegel W, Roeder C, Kasche D, Schmidt A, Lauer G, Thiele H G, Honold G, Pantel K, Riethmüller G
Abstract excerpt
We have analysed the expression of p53 at the mRNA level, and extensively at the protein level by immunostaining, Western blotting, and ELISA measurements revealing a p53 increase in 8 out of 14 cell lines established from human pancreatic carcinomas. The mRNA levels closely paralleled the protei...
Topics
- Base Sequence
- Blotting, Western
- Genes, p53
- Genes, ras
- Humans
- Immunoenzyme Techniques
- Immunohistochemistry
- Molecular Sequence Data
- Mutation
- Pancreas
- Pancreatic Neoplasms
- Point Mutation
- RNA, Messenger
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53