Article
p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Oncogene - 1 Feb 1993
Kalthoff H, Schmiegel W, Roeder C, Kasche D, Schmidt A, Lauer G, Thiele H G, Honold G, Pantel K, Riethmüller G
Abstract excerpt
We have analysed the expression of p53 at the mRNA level, and extensively at the protein level by immunostaining, Western blotting, and ELISA measurements revealing a p53 increase in 8 out of 14 cell lines established from human pancreatic carcinomas. The mRNA levels closely paralleled the protein levels in most of the cell lines. Overexpression of p53 in tumor cells correlated with mutations in the p53 gene....
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