Article
Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
The British journal of surgery - 1 Mar 1998
Gansauge S, Schmid R M, Muller J, Adler G, Mattfeldt T, Beger H G
Abstract excerpt
BACKGROUND: In patients suffering from chronic pancreatitis the risk for the development of pancreatic cancer ranges from 4 to 6 per cent. Various mutations are associated with pancreatic cancer, especially of p53 and K-ras. The incidence of these mutations in resected chronic pancreatitic tissue was investigated. METHODS: In the present study DNA from 80 samples of tissue from patients with chronic pancreatitis...
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