Article
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology - 1 Apr 1997
Dergham S T, Dugan M C, Kucway R, Du W, Kamarauskiene D S, Vaitkevicius V K, Crissman J D, Sarkar F H
Abstract excerpt
CONCLUSION: This study could not attribute survival differences to the coincident acquisition of two common genetic alterations, K-ras mutation and p53 overexpression in pancreatic adenocarcinoma patients. Additionally, our data indicate the converse to be true: Those patients lacking both K-ras mutation and aberrant p53 expression showed the shortest survival when compared with cases showing either alteration or...
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