Article
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology - 1 Apr 1997
Dergham S T, Dugan M C, Kucway R, Du W, Kamarauskiene D S, Vaitkevicius V K, Crissman J D, Sarkar F H
Abstract excerpt
CONCLUSION: This study could not attribute survival differences to the coincident acquisition of two common genetic alterations, K-ras mutation and p53 overexpression in pancreatic adenocarcinoma patients. Additionally, our data indicate the converse to be true: Those patients lacking both K-ras...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- DNA Primers
- Female
- Gene Expression
- Genes, p53
- Genes, ras
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Pancreatic Neoplasms
- Prognosis
- Survival Rate