Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells.

doi:10.1016/0014-5793(93)81283-6

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Article

Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells.

FEBS letters - 15 Feb 1993

Jakubowski H, Goldman E

Abstract excerpt

Homocysteine thiolactone is a product of an error-editing reaction, catalyzed by Escherichia coli and Saccharomyces cerevisiae methionyl-tRNA synthetases, which prevents incorporation of homocysteine into tRNA and protein both in vitro and in vivo. Here, homocysteine thiolactone is also shown to...

Topics

3T3 Cells
Animals
CHO Cells
Cell Line
Cricetinae
HeLa Cells
Homocysteine
Humans
Methionine
Methionine-tRNA Ligase
Mice
Mutation
Sulfur Radioisotopes
Temperature
Tumor Cells, Cultured

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