Article
Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells.
FEBS letters - 15 Feb 1993
Jakubowski H, Goldman E
Abstract excerpt
Homocysteine thiolactone is a product of an error-editing reaction, catalyzed by Escherichia coli and Saccharomyces cerevisiae methionyl-tRNA synthetases, which prevents incorporation of homocysteine into tRNA and protein both in vitro and in vivo. Here, homocysteine thiolactone is also shown to be synthesized by cultured mammalian cells such as human cervical carcinoma (HeLa), mouse renal adenocarcinoma (RAG),...
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