Article
Effect of methionine and nitrous oxide on homocysteine export and remethylation in fibroblasts from cystathionine synthase-deficient, cb1G, and cb1E patients.
Pediatric research - 1 Jan 1994
Christensen B, Rosenblatt D S, Chu R C, Ueland P M
Abstract excerpt
We investigated the nitrous oxide-induced inactivation of methionine synthase and the concurrent homocysteine (Hcy) export in mutant fibroblasts with defects in the homocysteine catabolizing enzyme, cystathionine beta-synthase, or in methionine synthase, which carries out homocysteine remethylati...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Biological Transport, Active
- Cell Line
- Culture Media
- Cystathionine beta-Synthase
- Fibroblasts
- Homocysteine
- Homocystinuria
- Humans
- Kinetics
- Methionine
- Methylation
- Mutation
- Nitrous Oxide