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Article

Cysteine control over glutathione homeostasis in Chinese hamster fibroblasts overexpressing a gamma-glutamylcysteine synthetase activity.

European journal of biochemistry - 1 Jun 1999

Vincent B R, Mousset S, Jacquemin-Sablon A

Abstract excerpt

Gamma-glutamylcysteine synthetase (GCS) catalyses the first step of glutathione (GSH) biosynthesis and is considered to be the rate-limiting step of this pathway. In several experimental systems, GCS overexpression has been associated with GSH pool expansion and drug resistance. In this report, we describe a mutant line of Chinese hamster fibroblasts that overexpress this activity by 4-5 times, due to the...

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Identifiers

PMID: 10411651
DOI: 10.1046/j.1432-1327.1999.00449.x

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