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Article

Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990

Jakubowski H

Abstract excerpt

Previous in vitro studies have established a pre-transfer proofreading mechanism for editing of homocysteine by bacterial methionyl-, isoleucyl-, and valyl-tRNA synthetases. The unusual feature of the editing is the formation of a distinct compound, homocysteine thiolactone. Now, two-dimensional TLC analysis of 35S-labeled amino acids extracted from cultures of the bacterium Escherichia coli reveals that the...

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Identifiers

PMID: 2191291
DOI: 10.1073/pnas.87.12.4504
PMCID: PMC54144

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