Article
Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Jakubowski H
Abstract excerpt
Previous in vitro studies have established a pre-transfer proofreading mechanism for editing of homocysteine by bacterial methionyl-, isoleucyl-, and valyl-tRNA synthetases. The unusual feature of the editing is the formation of a distinct compound, homocysteine thiolactone. Now, two-dimensional...
Topics
- Amino Acids
- Amino Acyl-tRNA Synthetases
- Escherichia coli
- Homocysteine
- Kinetics
- Methionine-tRNA Ligase
- Mutation
- Plasmids
- Sulfates
- Sulfur Radioisotopes