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Article

Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae.

The EMBO journal - 1 Mar 1991

Jakubowski H

Abstract excerpt

Homocysteine thiolactone is a product of an error-editing reaction, catalyzed by Escherichia coli methionyl-tRNA synthetase, which prevents incorporation of homocysteine into tRNA and protein, both in vitro and in vivo. Here, the thiolactone is also shown to occur in cultures of the yeast Saccharomyces cerevisiae. In yeast, the thiolactone is made from homocysteine in a reaction catalyzed by methionyl-tRNA...

Topics

Autoradiography
Chromatography, Thin Layer
Genotype
Homocysteine
Kinetics
Methionine-tRNA Ligase
Mutagenesis, Site-Directed
Plasmids
Saccharomyces cerevisiae
Sulfur Radioisotopes

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Identifiers

PMID: 2001674
DOI: 10.1002/j.1460-2075.1991.tb07986.x
PMCID: PMC452689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2001674-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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