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Article

Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.

The Journal of biological chemistry - 14 Sept 2012

Maclean Kenneth N, Greiner Lori S, Evans Jeffrey R, Sood Sudesh K, Lhotak Sarka, Markham Neil E, Stabler Sally P, Allen Robert H, Austin Richard C, Balasubramaniam Vivek, Jiang Hua

Abstract excerpt

Cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine) is a non-proteinogenic thioether containing amino acid. In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine β-synthase (CBS). Cystathionine is subsequently converted to cysteine plus ammonia and α-ketobutyrate by the action of...

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Identifiers

PMID: 22854956
DOI: 10.1074/jbc.M112.355172
PMCID: PMC3442531

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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