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Article

Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase.

The Journal of biological chemistry - 11 Aug 2006

Zimny Jaroslaw, Sikora Marta, Guranowski Andrzej, Jakubowski Hieronim

Abstract excerpt

Homocysteine (Hcy) editing by methionyl-tRNA synthetase results in the formation of Hcy-thiolactone and initiates a pathway that has been implicated in human disease. In addition to being cleared from the circulation by urinary excretion, Hcy-thiolactone is detoxified by the serum Hcy-thiolactonase/paraoxonase carried on high density lipoprotein. Whether Hcy-thiolactone is detoxified inside cells was unknown....

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PMID: 16769724
DOI: 10.1074/jbc.M603656200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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