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Article

Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.

Experimental cell research - 1 Feb 1990

Liteplo R G

Abstract excerpt

Our aim was to determine if the isolation of cells capable of proliferating in methionine-free homocysteine-containing medium, from the human MeWo-LC1 melanoma tumor cell line which is unable to proliferate or survive under such conditions, was associated with altered growth properties. Cells which were able to proliferate in methionine-free homocysteine-containing medium (homocysteine-responsive cells) were...

Topics

Adenosine
Cell Division
Culture Media
Deoxyadenosines
Homocysteine
Humans
Melanoma, Experimental
Methionine
Phenotype
S-Adenosylmethionine
Tetrahydrofolates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thionucleosides

Tumor Cells, Cultured

Source

Identifiers

PMID: 2298245
DOI: 10.1016/0014-4827(90)90314-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2298245-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.PMID 2298245Read ↗

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