Article
Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Trinidad A, Kirlin W G, Ogolla F, Andrews A F, Yerokun T, Ferguson R J, Brady P K, Hein D W
Abstract excerpt
Acetyl-coenzyme A (AcCoA)-dependent arylamine N-acetyltransferase (NAT) activity (EC 2.3.1.5) was examined in liver cytosol derived from homozygous rapid acetylator (Bio. 87.20) and homozygous slow acetylator (Bio. 82.73/H) Syrian inbred hamsters. Expression of NAT activity toward p-aminobenzoic...
Topics
- 4-Aminobenzoic Acid
- Acetylation
- Acetyltransferases
- Animals
- Chromatography, Ion Exchange
- Chromatography, Liquid
- Cricetinae
- Cytosol
- Genotype
- Isoenzymes
- Liver
- Mesocricetus