Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.

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Article

Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Yerokun T, Kirlin W G, Trinidad A, Ferguson R J, Ogolla F, Andrews A F, Brady P K, Hein D W

Abstract excerpt

Recent studies from our laboratory have shown relatively high levels of polymorphic N-acetyltransferase (NAT)(EC 2.3.1.5) activity toward carcinogenic arylamines in urinary bladder cytosol of humans and in the inbred hamster model of the N-acetylation polymorphism. The expression of this polymorphism is of interest because of the higher incidence of bladder cancer among human slow acetylators with documented...

Topics

4-Aminobenzoic Acid
Acetylation
Acetyltransferases
Aminosalicylic Acids
Animals
Arylamine N-Acetyltransferase
Carcinogens
Catalysis
Cricetinae
Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

In Vitro Techniques

Kinetics

Mesocricetus

Proteins

Urinary Bladder

Source

Open in PubMed

Identifiers

PMID: 2568902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2568902-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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