Article
p53 alterations in all stages of breast cancer.
Journal of surgical oncology - 1 Dec 1991
Davidoff A M, Kerns B J, Pence J C, Marks J R, Iglehart J D
Abstract excerpt
Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 73 (25%) of 291 primary invasive carcinomas, 13 (50%) of 26 lymph nodes containing metastatic breast cancer, and two of four...
Topics
- Base Sequence
- Breast Neoplasms
- Exons
- Female
- Gene Expression
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Mutation
- Neoplasm Staging
- Tumor Suppressor Protein p53