Maintenance of p53 alterations throughout breast cancer progression.

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Article

Maintenance of p53 alterations throughout breast cancer progression.

Cancer research - 15 May 1991

Davidoff A M, Kerns B J, Iglehart J D, Marks J R

Abstract excerpt

Overexpression of the nuclear phosphoprotein p53 is one of the most common abnormalities in primary human cancer and appears to be due to point mutation within a highly conserved region of the p53 gene which then encodes for a mutant, more stable protein. In this study different stages of breast...

Topics

Base Sequence
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Female
Humans
Immunohistochemistry
Molecular Sequence Data
Mutation
Neoplasm Invasiveness
Oligonucleotide Probes
RNA, Messenger
RNA, Neoplasm
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1850660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1850660-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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