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Article

Evidence for functional interaction between elongation factor Tu and 16S ribosomal RNA.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1993

Powers T, Noller H F

Abstract excerpt

Translation of the genetic code requires the accurate selection of elongation factor (EF)-Tu.GTP.tRNA ternary complexes at the ribosomal acceptor site, or A site. Several independent lines of evidence have implicated the universally conserved 530 loop of 16S rRNA in this process; yet its precise role has not been identified. Using an allele-specific chemical probing strategy, we have examined the functional...

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Identifiers

PMID: 8433994
DOI: 10.1073/pnas.90.4.1364
PMCID: PMC45873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for functional interaction between elongation factor Tu and 16S ribosomal RNA.PMID 8433994Read ↗

Dominant lethal mutations in a conserved loop in 16S rRNA.Semantic proximity Read ↗

A mutation at the universally conserved position 529 in Escherichia coli 16S rRNA creates a functional but highly error prone ribosome.Semantic proximity Read ↗

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.Semantic proximity Read ↗

Bases in 16S rRNA important for subunit association, tRNA binding, and translocation.Semantic proximity Read ↗

Alterations in the peptidyltransferase and decoding domains of ribosomal RNA suppress mutations in the elongation factor G gene.Semantic proximity Read ↗

An A to U transversion at position 1067 of 23 S rRNA from Escherichia coli impairs EF-Tu and EF-G function.Semantic proximity Read ↗

Testing constraints on rRNA bases that make nonsequence-specific contacts with the codon-anticodon complex in the ribosomal A site.Semantic proximity Read ↗

Base 2661 in Escherichia coli 23S rRNA influences the binding of elongation factor Tu during protein synthesis in vivo.Semantic proximity Read ↗

GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes.Semantic proximity Read ↗

Positions 13 and 914 in Escherichia coli 16S ribosomal RNA are involved in the control of translational accuracy.Semantic proximity Read ↗

A single base mutation at position 2661 in E. coli 23S ribosomal RNA affects the binding of ternary complex to the ribosome.Semantic proximity Read ↗

Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics.Semantic proximity Read ↗

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