Mutations dissociating the inhibitory activity of the pokeweed antiviral protein on eukaryote translation and Escherichia coli growth.

doi:10.1093/nar/21.18.4200

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Article

Mutations dissociating the inhibitory activity of the pokeweed antiviral protein on eukaryote translation and Escherichia coli growth.

Nucleic acids research - 11 Sept 1993

Dore J M, Gras E, Depierre F, Wijdenes J

Abstract excerpt

The pokeweed antiviral protein is a ribosome inactivating protein acting on eukaryotic as well as on prokaryotic ribosomes thus is toxic for both cell types. Using the PCR technique to clone the PAP open reading frame, we characterized two cDNAs coding for proteins inhibiting eukaryotic translati...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA, Complementary
Escherichia coli
Molecular Sequence Data
Mutation
N-Glycosyl Hydrolases
Open Reading Frames
Plant Proteins
Polymerase Chain Reaction
Protein Biosynthesis
Recombinant Proteins
Ribosome Inactivating Proteins, Type 1
Sequence Analysis, DNA

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Identifiers

PMID: 8414974
DOI: 10.1093/nar/21.18.4200
PMCID: PMC310050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8414974-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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