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Article

Pokeweed antiviral protein (PAP) mutations which permit E.coli growth do not eliminate catalytic activity towards prokaryotic ribosomes.

Nucleic acids research - 11 May 1994

Chaddock J A, Lord J M, Hartley M R, Roberts L M

Abstract excerpt

Pokeweed antiviral protein (PAP) has N-glycosidase activity towards both eukaryotic and prokaryotic ribosomes. This is in marked contrast with the A chains of type 2 ribosome inactivating proteins (RIPs) such as ricin and abrin, which inactivate only eukaryotic ribosomes. A recent report described spontaneous mutations in PAP that implicated specific amino acids to be involved in determining the activity of PAP...

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Identifiers

PMID: 8202351
DOI: 10.1093/nar/22.9.1536
PMCID: PMC308026

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Pokeweed antiviral protein (PAP) mutations which permit E.coli growth do not eliminate catalytic activity towards prokaryotic ribosomes.PMID 8202351Read ↗

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