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Article

A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template.

RNA (New York, N.Y.) - 1 Mar 2000

Hudak K A, Wang P, Tumer N E

Abstract excerpt

Pokeweed antiviral protein (PAP) is known to inactivate ribosomes by removal of a specific adenine from the sarcin/ricin (S/R) loop of the large rRNA, thereby inhibiting translation. We demonstrate here that in addition to the previously identified adenine (A4324), PAP removes another adenine (A4321) and a guanine (G4323) from the eukaryotic large rRNA. Recent results indicate that the antiviral activity of PAP...

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Identifiers

PMID: 10744021
DOI: 10.1017/s1355838200991337
PMCID: PMC1369919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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