Mutagenesis of Pseudomonas exotoxin in identification of sequences responsible for the animal toxicity.

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Article

Mutagenesis of Pseudomonas exotoxin in identification of sequences responsible for the animal toxicity.

The Journal of biological chemistry - 25 Sept 1990

Chaudhary V K, Jinno Y, Gallo M G, FitzGerald D, Pastan I

Abstract excerpt

Pseudomonas exotoxin (PE) is composed of three structural domains that are responsible for cell recognition, membrane translocation, and ADP-ribosylation. The deletion of the cell recognition domain (domain Ia) of PE results in a molecule that does not bind to target cells and has low toxicity in...

Topics

ADP Ribose Transferases
Amino Acid Sequence
Animals
Bacterial Toxins
Base Sequence
Cell Line
Cell Survival
Chromosome Deletion
Cloning, Molecular
Escherichia coli
Exotoxins
Genetic Vectors
Hydrogen Bonding
Lethal Dose 50
Mice
Models, Molecular
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 2118903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2118903-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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