Article
Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Chaudhary V K, Jinno Y, FitzGerald D, Pastan I
Abstract excerpt
Pseudomonas exotoxin (PE), a single-chain polypeptide toxin of 613 amino acids, consists of three functional domains: an amino-terminal receptor-binding domain, a middle translocation domain, and a carboxyl-terminal ADP-ribosylation domain. Deletion of as few as 2 or as many as 11 amino acids fro...
Topics
- ADP Ribose Transferases
- Adenosine Diphosphate Ribose
- Amino Acid Sequence
- Animals
- Bacterial Toxins
- Binding, Competitive
- Biological Transport
- Cell Survival
- Cells, Cultured
- Exotoxins
- Fluorescent Antibody Technique