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Article

Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers.

Journal of gastrointestinal and liver diseases : JGLD - 1 Mar 2007

Akkiprik Mustafa, Ataizi-Celikel Cigdem, Ataizi-Celikel Ciddem, Düşünceli Fikret, Sönmez Ozgür, Gulluoglu Bahadir M, Güllüoglu Bahadýr M, Sav Aydin, Sav Aydýn, Ozer Ayşe

Abstract excerpt

BACKGROUND AND AIMS: Genetic alterations of p53, K-ras and DCC genes have a pivotal role in the colorectal cancer progression. The aim of this study was to clarify the association between K-ras mutations, p53 aberrations and DCC loss of heterozygosity (LOH), with the patient outcome and tumor characteristics in 43 stage I-II colorectal cancer patients. METHODS: Mutations in exons 5-8 of the p53 gene and codon 12...

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PMID: 17410283

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DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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