Article
Experimental evidence for an alternative to directed mutation in the bgl operon.
Nature - 2 Apr 1992
Mittler J E, Lenski R E
Abstract excerpt
The directed mutation hypothesis suggests that some mutations occur more often when selectively advantageous than when neutral or disadvantageous, challenging the principle that the selective value of a mutation does not affect the rate of its occurrence. Mutations in the bgl operon of Escherichia coli have been reported to be a case of directed mutation. E. coli K12 strains chi342LD cannot grow on salicin but...
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