Article
Sustained outgrowth of autotumor-reactive T lymphocytes from human ovarian carcinomas in the presence of tumor necrosis factor alpha and interleukin 2.
Human immunology - 1 Jun 1990
Vaccarello L, Wang Y L, Whiteside T L
Abstract excerpt
Tumor-infiltrating lymphocytes (TIL) freshly isolated from human ovarian carcinomas were phenotyped (up to 75% CD3+ HLA-DR+ cells) and cultured in the presence of recombinant interleukin 2 and tumor necrosis factor alpha. In short-term cultures, an initial outgrowth of CD3+ CD8+ T lymphocytes res...
Topics
- Antigens, Differentiation, T-Lymphocyte
- Biological Factors
- CD8 Antigens
- Cytokines
- Cytotoxicity, Immunologic
- Female
- Humans
- Interleukin-2
- Ovarian Neoplasms
- Phenotype
- T-Lymphocytes
- T-Lymphocytes, Cytotoxic
- Tumor Necrosis Factor-alpha