Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and interleukin-2.

doi:10.1200/JCO.1997.15.2.796

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Article

Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and interleukin-2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 1997

Chang A E, Aruga A, Cameron M J, Sondak V K, Normolle D P, Fox B A, Shu S

Abstract excerpt

PURPOSE: In preclinical studies, we have reported the ability to induce immune T cells in lymph nodes (LN) primed by in vivo vaccination with tumor cells admixed with a bacterial adjuvant. These LN cells can be activated and expanded ex vivo for the successful immunotherapy of established tumors....

Topics

Adult
BCG Vaccine
CD3 Complex
Carcinoma, Renal Cell
Drug Screening Assays, Antitumor
Female
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Hypersensitivity, Delayed
Immunity, Cellular
Immunotherapy, Adoptive
Interferon-gamma
Interleukin-2

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney Neoplasms

Killer Cells, Lymphokine-Activated

Lymphocyte Activation

Lymphocytes, Tumor-Infiltrating

Male

Source

Open in PubMed

Identifiers

PMID: 9053507
DOI: 10.1200/JCO.1997.15.2.796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9053507-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.