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Article

Selection of a precore mutant of hepatitis B virus and reactivation of chronic hepatitis B acquired in childhood.

The Journal of pediatrics - 1 Oct 1993

Bortolotti F, Crivellaro C, Brunetto M R, Cadrobbi P, Bertolini A, Alberti A

Abstract excerpt

A 14-year-old girl with chronic hepatitis B had seroconversion from hepatitis B e antigen to antibody and achieved biochemical remission after 2 years. The disease reactivated 9 years later when a precore mutant had become the prevalent hepatitis B virus strain in serum. These results suggest tha...

Topics

Adolescent
Female
Hepatitis B
Hepatitis B Antibodies
Hepatitis B e Antigens
Hepatitis B virus
Hepatitis, Chronic
Humans
Italy
Longitudinal Studies
Mutation
Time Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Identifiers

PMID: 8410512
DOI: 10.1016/s0022-3476(05)80956-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8410512-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Selection of a precore mutant of hepatitis B virus and reactivation of chronic hepatitis B acquired in childhood.PMID 8410512Read ↗

Reactivation of precore variant hepatitis B virus in a child with severe aplastic anaemia.Semantic proximity Read ↗

Hepatitis may precede the occurrence of precore region mutation in hepatitis B virus genome during infection in young carriers.Semantic proximity Read ↗

Universal emergence of precore mutant hepatitis B virus along with seroconversion to anti-HBe irrespective of subsequent activity of chronic hepatitis B.Semantic proximity Read ↗

Precore region mutation in hepatitis B virus genome in early stage of infection: a study in hepatitis B e antigen-positive young carriers.Semantic proximity Read ↗

Mutations in the basic core promotor and the precore region of hepatitis B virus and their selection in children with fulminant and chronic hepatitis B.Semantic proximity Read ↗

Low frequency of precore hepatitis B virus mutants in anti-hepatitis B e-positive reactivation after loss of hepatitis B e antigen in patients with chronic hepatitis B.Semantic proximity Read ↗

Selection of a precore mutant after vertical transmission of different hepatitis B virus variants is correlated with fulminant hepatitis in infants.Semantic proximity Read ↗

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HBV pre-core mutant in genotype-D infected children is selected during HBeAg/anti-HBe seroconversion and leads to HBeAg negative chronic hepatitis B in adulthood.Semantic proximity Read ↗

Hepatitis B virus mutation in children.Semantic proximity Read ↗

Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.Semantic proximity Read ↗

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