Article
Precore region mutation in hepatitis B virus genome in early stage of infection: a study in hepatitis B e antigen-positive young carriers.
Journal of gastroenterology - 1 Aug 1994
Nguyen X T, Fukuda R, Fukumoto S
Abstract excerpt
To determine when the precore mutation at the 83rd nucleotide occurs, leading to the formation of a stop codon in the hepatitis B virus genome in carriers, which would indicate the presence of antibody to hepatitis B e antigen (anti-HBe), we investigated this mutation by direct sequencing and sub...
Topics
- Adolescent
- Alanine Transaminase
- Base Sequence
- Carrier State
- Child
- Female
- Genome, Viral
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Radioimmunoassay