Article
HBV pre-core mutant in genotype-D infected children is selected during HBeAg/anti-HBe seroconversion and leads to HBeAg negative chronic hepatitis B in adulthood.
Journal of medical virology - 1 Jul 2018
Colombatto Piero, Barbera Cristiana, Bortolotti Flavia, Maina Anna M, Moriconi Francesco, Cavallone Daniela, Calvo Pierluigi, Oliveri Filippo, Bonino Ferruccio, Brunetto Maurizia R
Abstract excerpt
Selection of HBeAg defective HBV mutants (mt) during childhood might influence infection outcome in adults. Aim of this study was to correlate the dynamics of pre-core HBV mutant (pre-C mt) selection with virological/clinical outcomes in children followed-up until adulthood. Eighty subjects (50-M/30-F), 70 HBeAg-positive (87.5%), and 10 (12.5%) HBeAg-negative/anti-HBe-positive at the admission, mostly genotype D...
Topics
- Adolescent
- Child
- Child, Preschool
- Female
- Genotype
- Hepatitis B Core Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Infant
- Longitudinal Studies
- Male