Article
Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.
Journal of medical virology - 1 Apr 1995
Karasawa T, Aizawa Y, Zeniya M, Kuramoto A, Shirasawa T, Toda G
Abstract excerpt
To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconver...
Topics
- Adult
- Aged
- Base Sequence
- Carrier State
- Case-Control Studies
- Chronic Disease
- DNA, Viral
- Female
- Gene Frequency
- Genetic Heterogeneity
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B Surface Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Interferon Type I
- Japan